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UIC Publications

2024

Barakat, M.; Chen, L.; David, B. P.; Shi, J.; Xu, A.; Skowron, K. J.; Johnson, T.; Woods, R.; Ankireddy, A.; Reddy, S. P.; Moore, T. W.; DiPietro, L. A. Non-Electrophilic NRF2 Activators Promote Wound Healing in Human Keratinocytes and Diabetic Mice and Demonstrate Selective Downstream Gene Targeting. Scientific Reports 2024, 14, 25258. doi: 10.1038/s41598-024-75786-3.

Durante, D.; Bott, R.; Cooper, L.; Owen, C. D.; Patten, J. J.; Zielinski, C.; Peet, N. P.; Davey, R A.; Gaisina, I.; Rong, L.; Moore, T. W. N-substituted Pyrrole-based Heterocycles as Broad-spectrum Filoviral Entry Inhibitors. Journal of Medicinal Chemistry 2024, 67, 13737-13764. doi: 10.1021/acs.jmedchem.4c00527.

Dean, T. T.; Jelú-Reyes, J.; Allen, A. C.; Moore, T. W. Peptide–Drug Conjugates: An Emerging Direction for the Next Generation of Peptide Therapeutics. Journal of Medicinal Chemistry 2024, 67, 1641-1661. doi: 10.1021/acs.jmedchem.3c01835.

Gaisina, I.; Li, P.; Du, R.; Cui, Q.; Dong, M.; Zhang, C.; Manicassamy, B.; Caffrey, M.; Moore, T. W.; Cooper, L.; Rong, L. An orally active entry inhibitor of influenza A viruses protects mice and synergizes with oseltamivir and baloxavir marboxil. Science Advances 2024, 10, eadk9004. doi: 10.1126/sciadv.adk9004.

2023

Skowron, K. J.; Baliga, C.; Johnson, T. L.; Kremiller, K. M.; Castroverde, A.; Dean, T. T.; Allen, A. C.; Lopez-Hernandez, A.; Aleksandrova, E; Klepacki, D.; Mankin, A. S.; Polikanov, Y. S.; Moore, T. W. Structure-activity relationships of the antimicrobial peptide natural product apidaecin. Journal of Medicinal Chemistry 2023, 66, 11831-11842. doi:  10.1021/acs.jmedchem.3c00406.

Villegas, J. A.; Vaid, T. M.; Johnson, M. E.; Moore, T. W. Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Computational and Structural Biotechnology Journal 2023, 21, 1885-1892. doi: 10.1016/j.csbj.2023.02.049.

2022

Alqarni, S. A.; Cooper, L. Achi, J. G.; Bott, R.; Sali, V. K.; Brown, A.; Santarsiero, B. D.; Krunic, A.; Manicassamy, B.; Peet, N. P.; Zhang, P.; Thatcher, G. R. J.; Gaisina, I.; Rong, L.; Moore, T. W. Synthesis, Optimization, and Structure–Activity Relationships of Imidazo[1,2-a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses. Journal of Medicinal Chemistry 2022, 65, 14104–14120. doi: 10.1021/acs.jmedchem.2c01329.

Ren, P.; Tiede, C.; Fanning, S. W.; Adams, T.; Speirs, V.; Nelson, E. R.; Cheng, C.; Moore, T. W.; Greene, G. L.; Tomlinson, D.; Selvin, P. R. Labeling of a Mutant Estrogen Receptor with an Affimer in a Breast Cancer Cell Line. Biophysical Journal 2022. doi: https://doi.org/10.1016/j.bpj.2022.06.028.

Naidu, S. D.; Dikovskaya, D.; Moore, T. W.; Dinkova-Kostova, A. T. Detection of thermal shift in cellular Keap1 by protein-protein interaction inhibitors using immunoblot- and fluorescence microplate-based assays. STAR Protocols 2022, 3, 101265.

Adams, A.; Altman, R.; Brai, A.; Golden, J.; La Regina, G.; Li, Z.; Moore, T. W.; Pomerantz, W.; Rajapaksa, N. An Innovation 10 Years in the Making: The Stories in the Pages of ACS Medicinal Chemistry Letters. ACS Medicinal Chemistry Letters 2022, 13, 540–545.

2021

Naidu, S. D.; Suzuki, T.; Dikovskaya, D.; Knatko, E. V.; Higgins, M.; Sato, M.; Novak, M.; Villegas, J. A.; Moore, T. W.; Yamamoto, M.; Dinkova-Kostova, A. T. The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience 2021, doi: 10.1016/j.isci.2021.103703.

Amaya, M.; Cheng, H.; Borisevich, V.; Navaratnarajah C. K.; Cooper, L.; Moore, T. W.; Gaisina, I. N.; Geisbert, T. W.; Rong, L.; Broder, C. C. A recombinant Cedar virus based high-throughput screening assay for henipavirus antiviral discovery. Antiviral Research 2021, 105084. doi: 10.1016/j.antiviral.2021.105084.

Moore, T.W. In This Issue, Volume 12, Issue 8. ACS Medicinal Chemistry Letters 2021, 12, doi: 10.1021/acsmedchemlett.1c00395.

Horie, Y.; Suzuki, T.; Inoue, J.; Iso, T.; Wells, G.; Moore, T. W.; Mizushima, T.; Dinkova-Kostova, A.; Kasai, T.; Kamei, T.; Koshiba, S.; Yamamoto, M. Molecular basis for the disruption of Keap1-Nrf2 interaction via Hinge & Latch mechanism. Communications Biology 2021, 4, 1– doi: 10.1038/s42003-021-02100-6.

Zink, K. E.; Ludvik, D. A.; Lazzara, P. R.; Moore, T. W.; Mandel, M. J.; Sanchez, L. A Small Molecule Coordinates Symbiotic Behaviors in a Host Organ. mBio 2021, 12, e03637-20. doi: 10.1128/mBio.03637-20.

Baliga, C.; Brown, T.; Florin, T.; Colon, S.; Shah, V.; Skowron, K.; Kefi, A.; Szal, T.; Klepacki, D.; Moore, T. W.; Vázquez-Laslop, N.; Mankin, A. S. Charting the sequence-activity landscape of peptide inhibitors of translation termination. Proceedings of the National Academy of Sciences, USA 2021, 118, e2026465118. doi: 10.1073/pnas.2026465118

2020

Moore, T. W. In this Issue, Volume 11, Issue 12. ACS Medicinal Chemistry Letters 2020, 11, 2342. doi: 10.1021/acsmedchemlett.0c00616

Mbachu, O.; Howell, C.; Simmler, C.; Malca Garcia, G.; Skowron, K. M.; Dong, H.; Ellis, S.; Hajirahimkhan, A.; Chen, S-.N.; Nikolic, D.; Moore, T. W.; Vollmer, G.; Pauli, G. F.; Bolton, J. L.; Dietz, B. SAR Study on Estrogen Receptor α/β Activity of (Iso)Flavonoids: Importance of Prenylation, C-ring (Un)Saturation, and Hydroxyl Substituents. Journal of Agricultural and Food Chemistry 2020, 68, 10651-10663. doi: 10.1021/acs.jafc.0c03526.

Clark, L. F.; Moore, T. W. In This Issue, Volume 11, Issue 6. ACS Medicinal Chemistry Letters 2020, 11, 1062. doi: 10.1021/acsmedchemlett.0c00286.

Lazzara, P. R.; Jain, A. D.; Maldonado, A. C.; Richardson, B. G.; Skowron, K. J.; David, B. P.; Siddiqui, Z.; Ratia, K. M.; Moore, T. W. Synthesis and Evaluation of Non-covalent Naphthalene-Based KEAP1-NRF2 Inhibitor Analogs. ACS Medicinal Chemistry Letters 2020, 11, 521-527.  doi: 10.1021/acsmedchemlett.9b00631.

Lazzara, P. R.*; David, B. P.*; Ankireddy, A.; Richardson, B. G.; Dye, K.; Ratia, K.; Reddy, S. P.; Moore, T. W. Isoquinoline Kelch-like ECH-Associated Protein 1-Nuclear Factor (Erythroid-derived 2)-like 2 (KEAP1-NRF2) Inhibitors with High Metabolic Stability. Journal of Medicinal Chemistry 2020, 63, 6547-6560. (*equal contribution) doi: 10.1021/acs.jmedchem.9b01074.

Moore, T. W. In This Issue, Volume 11, Issue 2. ACS Medicinal Chemistry Letters 2020, 11, 90. doi: 10.1021/acsmedchemlett.0c00038

Lazzara, P. R.; Moore, T. W. Scaffold-Hopping as a Strategy to Address Metabolic Liabilities of Aromatic Compounds. RSC Medicinal Chemistry 2020, 11, 18–29. doi: 10.1039/C9MD00396G.

2019

Moore, T. W. In This Issue, Volume 10, Issue 9. ACS Medicinal Chemistry Letters 2019, 10, 1242. doi: 10.1021/acsmedchemlett.9b00389

Moore, T. W.; Frasor, J. Editorial for Special Issue on “Alternative Nuclear Receptor Ligands”. Molecular and Cellular Endocrinology 2019, 493, 110479. doi: 10.1016/j.mce.2019.110479.

Adams, A. M.; Moore, T. W. In This Issue, Volume 10, Issue 7. ACS Medicinal Chemistry Letters 2019, 10, 1015. doi: 10.1021/acsmedchemlett.9b00288.

Skowron, K. J.; Booker, K. M.; Cheng, C.; Creed, S.; David, B. P.; Lazzara, P. R.; Lian, A.; Siddiqui, Z.; Speltz, T. E.; Moore, T. W. Steroid Receptor/Coactivator Binding Inhibitors: An Update. Molecular and Cellular Endocrinology 2019, 493, 110471. doi: 10.1016/j.mce.2019.110471.

Skowron, K. J.; Speltz, T. E.; Moore, T. W. Recent Structural Advances in Constrained Helical Peptides.  Medicinal Research Reviews 2019, 39, 749-770. doi: 10.1002/med.21540.

2018

Richardson, B. G.; Jain, A. D.; Potteti, H.; Lazzara, P. R.; David, B. P.; Tamatam, C.; Choma, E.; Skowron, K.; Dye, K.; Siddiqui, Z.; Wang, Yue-Ting; Krunic, A.; Reddy, S. P.; Moore, T. W. Replacement of a Naphthalene Scaffold in Kelch-like ECH-Associated Protein 1 (KEAP1)/Nuclear factor (erythroid-derived 2)-like 2 (NRF2)Inhibitors. Journal of Medicinal Chemistry 2018, 61, 8029-8047. doi: 10.1021/acs.jmedchem.8b01133

David, B. P.; Dubrovskyi, O.; Speltz, T. E.; Wolff, J. J.; Frasor, J.; Sanchez, L. M.; Moore, T. W. Using Tumor Explants for Imaging Mass Spectrometry Visualization of Unlabeled Peptides and Small Molecules.  ACS Medicinal Chemistry Letters 2018, 9, 768-772.  doi: 10.1021/acsmedchemlett.8b00091

Speltz, T. E.; Mayne, C. G.; Fanning, S. W.; Siddiqui, Z.; Tajkhorshid, E.; Greene, G. L.; Moore, T. W. A ‘Cross-Stitched’ Peptide with Improved Helicity and Proteolytic Stability. Organic and Biomolecular Chemistry 2018, 16, 3702-3706. doi: 10.1039/C8OB00790J. PMID: 29725689, PMCID: PMC5993042

Speltz, T. E.; Danes, J. M.; Stender, J. D.; Frasor, J. M.; Moore, T. W. A cell-permeable stapled peptide inhibitor of the estrogen receptor/coactivator interaction. ACS Chemical Biology 2018, 13, 676-684. doi: 10.1021/acschembio.7b01016.

Yao, Y.; Delgado-Rivera, L.; Samareh Afsari, H.; Yin, L.; Thatcher, G. R. J.; Moore, T. W.; Miller, L. W. Time-gated detection of enzymatically produced hydrogen sulfide: design, synthesis and application of lanthanide based probe. Inorganic Chemistry 2018, 57, 681-688. doi: 10.1021/acs.inorgchem.7b02533.

Popovich, N. G.; Okorie-Awe, C.; Crawford, S. Y.; Balcazar, F. E.; Vellurattil, R. P.; Moore, T. W.; Schriever, A. E. Assessing Students' Impressions of the Cultural Awareness of College of Pharmacy Faculty and Students. American Journal of Pharmaceutical Education 2018, 82, 6161. doi: 10.5688/ajpe6161.

2017

Yao, Y.; Kong, C.; Yin, L.; Jain, A. D.; Ratia, K.; Thatcher, G. R.; Moore, T. W.; Driver, T. G.; Miller, L. W. Time-gated detection of cystathionine γ-lyase activity and inhibition with a selective, luminogenic hydrogen sulfide sensor.  Chemistry – A European Journal 2017, 23, 752. doi: 10.1002/chem.201604786. PMID: 27734530.

2016

Speltz, T. E.; Fanning, S. W.; Mayne, C. G.; Fowler, C.; Tajkhorshid, E.; Greene, G. L.; Moore, T. W. Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction. Angewandte Chemie International Edition 2016, 55, 4252-4255. doi: 10.1002/anie.201510557 and 10.1002/ange.201510557. PMID: 26928945.

Xiong, R.; Patel, H.; Gutgesell, L.; Zhao, J.; Delgado-Rivera, L.; Pham, T.; Zhao, H.; Carlson, K. E.; Martin, T. F.; Katzenellenbogen, J. A.; Moore, T. W.; Tonetti, D.; Thatcher, G. R. J. Selective human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer. Journal of Medicinal Chemistry 2016, 59, 219-237. doi: 10.1021/acs.jmedchem.5b01276.

2015

Jain, A. D.; Potteti, H.; Richardson, B. G.; Kingsley, L.; Luciano, J. P.; Ryuzoji, A. F.; Lee, H.; Krunic, A.; Mesecar, A. D.; Reddy, S. P.; Moore, T. W. Probing the Structural Requirements of Non-electrophilic Naphthalene-Based Nrf2 Activators. European Journal of Medicinal Chemistry 2015,103, 252-268. doi:10.1016/j.ejmech.2015.08.049.

Richardson, B. G.; Jain, A. D.; Speltz, T. E.; Moore, T. W. Non-electrophilic modulators of the canonical Keap1/Nrf2 pathway. Bioorganic and Medicinal Chemistry Letters 2015, 25, 2261-2268. doi: 10.1016/j.bmcl.2015.04.019.

Publications from work before UIC

Moore, T. W.; Gunther, J. R.; Katzenellenbogen, J. A. Estrogen receptor alpha/co-activator interaction assay - TR-FRET. In PROTEIN-PROTEIN INTERACTIONS: Methods and Applications; Second Edition. Methods in Molecular Biology; C. Meyerkord and H. Fu, Eds.; Humana Press: New York, 2015, 1278, p. 545–553. doi: 10.1007/978-1-4939-2425-7_36. PMID: 25859975, PMCID: PMC4893311.

Zhu, S.; Kisiel, W.; Lu, Y. J.; Petersen, L. C.; Ndungu, J. M.; Moore, T. W.; Parker, E. T.; Sun, A.; Sarkaria, J. N.; Snyder, J. P.; Liotta, D. C.; Brat, D. J.; El-Rayes, B. F.; Shoji, M. Visualizing cancer and response to therapy in vivo using Cy5.5-labeled factor VIIa and anti-tissue factor antibody. Journal of Drug Targeting 2014, 23, 257– doi: 10.3109/1061186X.2014.988217. PMID: 25510254, PMCID: PMC4625384.

Zhu, S.; Kisiel, W.; Lu, Y. J.; Petersen, L. C.; Ndungu, J. M.; Moore, T. W.; Parker, E. T.; Sun, A.; Liotta, D. C.; El-Rayes, B. F.; Brat, D. J.; Snyder, J. P.; Shoji, M. Tumor angiogenesis therapy using targeted delivery of paclitaxel to the vasculature of breast cancer metastases. Journal of Drug Delivery 2014, 2014, Article ID 865732, 12 pages. doi: 10.1155/2014/865732. PMID: 25574399. PMCID: PMC4273585.

Grimmer, C.; Moore, T. W.; Padwa, A.; Prussia, A.; Wells, G.; Wu, S.; Sun, A.; Snyder, J. P. Antiviral Atropisomers: Conformational Energy Surfaces by NMR for Host-Directed Myxovirus Blockers. Journal of Chemical Information and Modeling 2014, 54, 2214– doi: 10.1021/ci500204j. PMID: 25058809.

Zhu, S.; Moore, T. W.; Morii, N.; Howard, R. B.; Culver, D.; Arrendale, R. F.; Reddy, P.; Evers, T. J.; Zhang, H.; Sica, G.; Sun, A.; Fu, H.; Khuri, F. R.; Shin, D. M.; Snyder, J. P.; Shoji, M. Synthetic Curcumin Analog UBS109 Inhibits the Growth of Head and Neck Squamous Cell Carcinoma Xenografts. Current Cancer Drug Targets 2014, 14, 380– doi: 10.2174/1568009614666140312163524. PMID: 24628271.

Yamaguchi, M.; Zhu, S.; Zhang, S.; Wu, D.; Moore, T. M.; Snyder, J. P.; Shoji, M. Curcumin Analogue UBS109 Prevents Bone Loss in Breast Cancer Bone Metastasis Mouse Model: Involvement in Osteoblastogenesis and Osteoclastogenesis. Cell and Tissue Research 2014, 357, 245–252. doi: 1007/s00441-014-1846-4. PMID: 24723227.

Moore, T. W.; Zhu, S.; Randolph, R.; Shoji, M.; Snyder, J. P. Liver S9 Fraction-Derived Metabolites of Curcumin Analogue UBS109. ACS Medicinal Chemistry Letters 2014, 5, 288-292. doi: 10.1021/ml4002453.

Moore, T. W.; Sana, K.; Yan, D.; Krumm, S. A.; Thepchatri, P.; Snyder, J. P.; Marengo, J.; Arrendale, R. F.; Prussia, A. J.; Natchus, M. G.; Liotta, D. C.; Plemper, R. K.; Sun, A.  Synthesis and Metabolic Studies of Host-Directed Inhibitors for Antiviral Therapy ACS Medicinal Chemistry Letters 2013, 4, 762-767. doi: 10.1021/ml400166b. PMID: 23956816. PMCID: PMC3743129.

Brown, A.; Shi, Q.; Moore, T. W.; Yoon, Y.; Prussia, A.; Maddox, C.; Liotta, D. C.; Shim, H.; Snyder, J. P.  Monocarbonyl Curcumin Analogs: Heterocyclic Pleiotropic Kinase Inhibitors that Mediate Anti-Cancer Properties.  Journal of Medicinal Chemistry 2013, 56, 3456-3466. doi: 10.1021/jm4002692. PMID: 23550937.

Moore, T. W.; Sana, K.; Yan, D.; Thepchatri, P.; Ndungu, J. M.; Saindane, M. T.; Natchus, M. G.; Liotta, D. C.; Plemper, R. K.; Snyder, J. P.; Sun, A.  Asymmetric Synthesis of Host-Directed Inhibitors of Myxoviruses. Beilstein Journal of Organic Chemistry 2013, 9, 197–203. doi: 10.3762/bjoc.9.23. PMID: 23400228. PMCID: PMC3566758.

Yamaguchi, M.; Moore, T. W.; Sun, A.; Snyder, J. P.; Shoji, M.  Novel curcumin analogue UBS109 potently stimulates osteoblastogenesis and suppresses osteoclastogenesis in vitro. Integrative Biology 2012, 4, 905-913. doi: 10.1039/c2ib20045g. PMID: 22751853.

Zhu, S.; Moore, T. W.; Lin, X.; Morii, N.; Mancini, A.; Howard, R. B.; Culver, D.; Arrendale, R. F.; Reddy, G. P.; Evers, T. J.; Zhang, H.; Sica, G.; Chen, Z. G.; Sun, A.; Fu, H.; Khuri, F. R.; Shin, D. M.; Snyder, J. P.; Shoji, M. Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts. Integrative Biology 2012, 4, 633-640. doi: 10.1039/c2ib20007d.

Olivera, A.; Moore, T. W.; Sun, A.; Hu, F.; Liotta, D. C.; Snyder, J. P.; Shim, H.; Marcus, A. I.; Miller, A. H.; Pace, T. W .W.  Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties. International Immunopharmacology 2012, 12, 368-377. doi: 10.1016/j.intimp.2011.12.009. PMID: 22532032. PMCID: PMC3734847

Sun, A.; Moore, T. W.; Gunther, J. R.; Kim, M. S.; Rhoden, E.; Du, Y.; Fu, H.; Snyder, J. P.; Katzenellenbogen, J. A.  Discovering Small Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency. ChemMedChem 2011, 6, 654-666. doi: 10.1002/cmdc.201000507. PMID: 21365764. PMCID: PMC3177402.

Moore, T. W.; Gunther, J. R.; Katzenellenbogen, J. A. Probing the Topological Tolerance of Multimeric Protein Interactions: Evaluation of anEstrogen/Synthetic Ligand for FK506 Binding Protein Conjugate. Bioconjugate Chemistry 2010, 21, 1880-1889. doi: 10.1021/bc100266v. PMID: 20919698. PMCID: PMC2967433.

Moore, T. W.; Mayne, C. G.; Katzenellenbogen, J. A. Not picking pockets: Nuclear Receptor Alternate-site Modulators (NRAMs). Molecular Endocrinology 2010, 24, 683-695. doi: 10.1210/me.2009-0362. PMID: 19933380. PMCID: PMC2852352.

Moore, T. W.; Katzenellenbogen, J. A. Inhibitors of nuclear hormone receptor/coactivator interactions. Annual Reports in Medicinal Chemistry 2009, 44, 443-457. doi:10.1016/S0065-7743(09)04421-2.

Gunther, J. R.; Du, Y.; Rhoden, E.; Lewis, I.; Revennaugh, B.; Moore, T. W.; Kim, S. H.; Dingledine, R.; Fu, H.; Katzenellenbogen, J. A. A set of time-resolved fluorescence resonance energy transfer assays for the discovery of inhibitors of estrogen receptor-coactivator binding. Journal of Biomolecular Screening 2009, 14, 181-193. doi: 10.1177/1087057108329349. PMID: 19196699. PMCID: PMC2731238.

Gunther, J. R.; Moore, T. W.; Collins, M. L.; Katzenellenbogen, J. A. Amphipathic benzenes are designed inhibitors of the estrogen receptor α/steroid receptor coactivator interaction. ACS Chemical Biology 2008, 3, 282-286. doi: 10.1021/cb800056r. PMID: 18484708. PMCID: PMC2427189.

Clews, P. K.; Douthwaite, R. E.; Kariuki, B. M.; Moore, T.; Taboada, M. Layered compounds incorporating 9,9'-spirobifluorene: Hydrogen-bonded and metal-organic networks derived from 9,9'-spirobifluorene-2,2',7,7'-tetracarboxylic acid. Crystal Growth and Design 2006, 6, 1991-1994. doi:10.1021/cg060007d.

Moore, T.; Kiely, C.; Reeves, P. C. Electronic properties of the trimethylenemethaneiron tricarbonyl group. Journal of Organometallic Chemistry 2001, 620, 308-312. doi:10.1016/S0022-328X(00)00812-3.